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-The Ultimate Recomping/Bulking Prohormone!
~Introduction to 2-Androstenone:
2-Androstenone or 2-Andro, is sometimes referred to by its synonyms Delta-2, Delta-2- androst-17- one, 17-Oxo- 5a-androst- 2-ene, (+)-Androst- 2-en- 17-one or 2-androsten- 17-one and occasionally by its nomenclature 5a-Androst- 2-ene- 17-one, 2-Andro is a naturally occurring human metabolite of DHEA, as well as a human pheromone due to being an Androsterone metabolite found on the human skin. It is also a naturally occurring pheromone in elephants and boars, and can be found in commonly eaten animal/game meats. [1, 2, 3, 4, 10] Since this compound is already ingested in the human diet, and is ametabolite of a pre-existing supplement, it meets the requirements of DSHEA compliance.
Perhaps most interestingly 2-Andro is also a prohormone. Now, in the supplement industry the words
prohormone and DS are frequently used interchangeably, but this practice is incorrect,as these words carry different meanings. And though 2-Andro is indeed a prohormone because it requires conversion to its active form, it is not a DS because it is naturally occurring compound and has not been modified in any way.
So what kind of prohormone is 2-Andro? Well, its a one-step conversion precursor, and like DHEA and 4-Androstenedione it also has a 17-keto function, which is reduced by interaction with the 17b-HSD enzyme in vivo to the active hormone 2-Androstenol (17b-hydroxy- 5a-androst- 2-ene; 5a-androst- 2-en-17b-ol), which is also known as Desoxytestosterone and is sometimes referred to as Unmethylated P-Plex, This 17b-hydroxylated metabolite is responsible for the anabolic and androgenic effects seen with this compound. Though, even before conversion takes place, 2-Andro is weakly active itself much like other non-17a- alkylated prohormones such as Boldione, 4-AD and 11-OXO.
-One- Step Conversion Prohormone:
2-Androstenone (via the 17b-HSD enzyme) -> 2-Androstenol (Desoxytestosterone; Unmethylated P-Plex)
Regarding the characteristics of 2-Andro, it does not aromatize (due to the lack of a 3-keto and 4-ene), meaning it wont convert to Estrogen, this makes it a dry compound with a reduced risk of water retention, bloating and gynecomastia (enlarged breasts in men). Another important characteristic of 2-Andro is that its non-methylated (not 17a-methylated) unlike other prohormones such as Halodrol, so there is no need for strong liver support like TUDCA while using 2-Andro because it is not hepatotoxic.
On the topic of 2-Andro’s target hormone, 2-Androstenol was found to have no activity by oral administration according to the researchers at Searle,  possibly because 2-Androstenol is not water soluble and thus cannot be absorbed by the small intestine, unlike 2-Androstenone.  This makes the prospect of orally administering 2-Andro to raise in vivo levels of Desoxytestosterone far more logical than orally administering Desoxytestosterone outright.
Another point to address is why 2-Androstenol is commonly referred to as Unmethylated P-Plex. To convey this simplistically, compare both of the compounds names and you can clearly see Desoxytestosterone is simply Desoxymethyltestosterone without the methyl. In fact, Madol/P-Plex is a synthetically modified form of 2-Androstenol.
Desoxytestosterone = 2-Androstenol; Unmethylated P-Plex
Desoxymethyltestosterone = Madol; P-Plex
Now, despite how similar these two compounds appear, they are different in several important ways.
Since 2-Androstenol is non-methylated it is non-orally active, unlike Madol/P-Plex. (Of course this issue is overcome by using its precursor, 2-Andro) This also means 2-Androstenol is not as strong as Madol/P-Plex, due to the methyl group increasing anabolic and androgenic activity. However we must keep in mind that due to 2-Androstenol being non-methylated it lacks the notorious hepatotoxicity that was associated with Madol/P-Plex, making it a far less toxic compound by comparison.
~Effects of 2-Andro:
It is worth highlighting the numerous effects that 2-Andro has, and how it could be a beneficial addition to a cycle:
-Anti- Catabolic (Muscle mass retention in a caloric deficit/while cutting)
-Decreased Body Fat
-Enhanced Muscle Pumps
-Increased Lean Body Mass (Via enhanced protein synthesis)
-Increased Recovery Speed
-Muscle Hardening (Increased muscle hardness)
In the past logs of 2-Andro seemed to yield positive results with minimal side effects within the four week time span. However, due its mild nature regarding side effects it can easily be run longer than four weeks, such as six to eight weeks in length. Because it's un-methylated, it stacks quite well with methylated compounds without increasing hepatotoxicity
~Side Effects of 2-Andro:
According to anecdotal reports, 2-Andro has minimal side effects, the most common being slight bloating, water retention and fatigue. However, as with all hormonal products it carries the potential of side effects such as acne, acceleration of male pattern baldness (if genetically susceptible), and increased or decreased sex drive, though rarely experienced. Due to the risk of masculinization (virilizing side effects), this compound is unsuitable for women and children.
~Dosing, Cycle Length, Stacking and Timing:
2-Andro is best utilized during bulking or recomping phases. When used as a standalone, 500mg daily for 30-60 days is regarded as the optimal dosage and cycle length. Because of its mild nature as a standalone, it is considered to be a fantastic beginner-level compound for those looking to run their first cycle, much like 11-Ketotestosterone.
However it is not uncommon to see experienced lifters with more than 2 cycles under their belt stack it with other compounds. Due to its non-methylated nature, it can stack with virtually any popular DS or prohormone. Its an extremely versatile compound that can fit into essentially any cycle.
~Post-Cycle Therapy (PCT) for 2-Andro:
2-Andro is capable of suppressing the HPTA; therefore it is recommended that at the very least SUP3R PCT and or TEST1FY be used.
~2-Androstenone Example Cycles Stacking Guidelines:
Though there are many ways 2-Andro can be utilized, here are just a few examples to better illustrate the versatility of the compound. Note: These are just simple examples, and cycles can be ran longer than 4 weeks, dosed at different times, and stacked with other compounds.
*Beginner – Standalone Cycle: (30 Day Cycle, Over 4 Weeks)
-2- Andro – 500/500/500/500
*Advanced/Experienced – Bulking Cycle: (30 Day Cycle, Over 4 Weeks)
-2- Andro — 500/500/500/500
-1- Andro — 330/330/330/330 (1 bottle Olympus UK SUP3R-1 ELITE – 90 Caps)
-Trest — — — 100/100/100/100 (1 bottle Olympus UK TR3ST – 120 Caps)
*Advanced/Experienced – Recomp Cycle: (30 Day Cycle, Over 4 Weeks)
-2- Andro – 500/500/500/500
-1- Andro – 330/330/330/330 (1 bottle Olympus UK SUP3R-1 ELITE – 90 Caps)
-11- KT — — 250/250/250/250 (1 bottle Olympus UK SUP3R-11)
*Advanced/Experienced – Cutting Cycle: (30 Day Cycle, Over 4 Weeks)
-2- Andro — –500/500/500/500
-Epi- Andro – 1000/1000/1000/1000 (1 bottle Olympus UK SUP3R-EPI ELITE – 120 Caps)
-IGNIT3 — — — 5/5/5/5 [Caps per day] (1 bottle Olympus Labs IGNIT3 – 150 Caps)
*On Cycle Therapy (OCT): (30 Days, Over 4 Weeks)
-Olympus Labs AR1MACARE PRO (As indicated on label)
*Post Cycle Therapy (PCT): (30 Days, Over 4 Weeks)
-Olympus Labs SUP3R PCT (As indicated on label)
Directions: Take one (1) capsule two (2) times daily.
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