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Chlorophytum Borivilanium (also known as Safed Musli) is an herb fond in Ayurveda mostly known for its aphrodisiac activity. Over the past 10 years or so, numerous studies have been conducted into its effects. It is mainly used in India, and has been marketed as an “all-natural” version of Viagra™. It is also purported to have immunomodulatory and anticancer activities. Chlorophytum Borivilanium use has been shown to enhance the quality of semen and enhance male reproductive potentiality. It also leads to a significant increase in semen count, volume, and serum testosterone levels. Trials combining Chlorophytum Borivilanium with L-dopa (both components of Growth Factor XT) have shown an increase of sleep quality in participants involved in the group using these two ingredients vs. placebo. This very same combination has also shown to lead to an increase in serum growth hormone in men who exercised regularly (1-5).
L-Carnitine L-Tartrate (LCLT) can possibly increase the amount of fat burned during resistance training, and enhance the consumption of fat as a source of fuel. LCLT supplementation can also result an increase in the contents of androgen receptors, which made lead to increased protein synthesis. Research also suggests that less muscle damage occurs due to this increased androgen receptor content, which in turn leads to a promotion in recovery. In addition, LCLT may also lead to a reduction in myoglobin and creatine kinase after exercise (6-10).
Green Tea extracts are one of the most common supplements on the market. EGCG, a constituent of green tea extract, is a mild decarboxylase inhibitor. Long term use of EGCG suggests that it suppresses muscle oxidative stress and inflammation, which may lead to a recovery in physical performance. Using green tea extract has been shown to possibly have beneficial effects on cholesterol and glucose related markers. Green Tea extract is twice as potent as vitamin C in terms of antioxidant activity. Green Tea extract use may potentially have anticancer capabilities, and may be helpful in treating chronic inflammatory states (11-15).
Administration of GABA has been consistently shown to lead to increases in plasma growth hormone levels. GABA usage may also lead to an elevation in both resting and post-exercise levels of immunoreactive growth hormone and immunofunctional growth hormone release. It is speculated that this may lead to resistance training induced muscular adaptations (increases in lean muscle from working out) (16-17).
3-OH-GABA is more potent than regular GABA and is more selective of GABAA receptor sites (generally GABA agonists are active at GABAA and GABAB sites) than most GABA agonists. Therefore, a much lower dose is needed because of the increased potency.
L-Dopa supplementation has been reported to have a variety of sexual and non-sexual benefits. These benefits may include an increase in libido, improved semen quality, and due to the extra blood flow, a temporary increase in penile thickness. Other benefits may include a potential decrease in prolactin and improved blood pressure. Studies have also shown that L-Dopa stimulates the release of hypothalamic hGHRH and may increase circulating testosterone and gh levels.
In addition to L-Dopa’s standalone benefits, combining L-Dopa with Green Tea extract (due to its EGCG content, which acts as a catechol-o- methyltransferase inhibitor) may have a synergistic effect on growth hormone levels. Also, in trials, combining Chlorophytum Borivilanium with L-dopa (both components of Growth Factor XT) have shown an increase of sleep quality in participants involved in the group using these two ingredients vs. placebo. This very same combination has also shown to lead to an increase in serum growth hormone in men who exercised regularly (18-26).
Theanine, a naturally occurring amino acid in tea, has been shown to have a significant anti-stress effect on animals under psychosocial stress. A study has shown the anti-stress effect of Theanine on humans in students during pharmacy practice. Another study has shown Theanine not only reduces anxiety but also attenuates the blood pressure increase in high stress response adults. Theanine administration has also shown results in neuroprotection and prevents glutamate receptor agonist-mediated injury in the rat model of cerebral ischemia-reperfusion. Theanine also possesses a preventative effect on stress-induced impairments of hippocampal long-term potentiation and recognition memory. Theanine intake can also lead to an activation of ERK/eNOS resulting in enhanced NO production (i.e. vasodilation) (27-32).
Pyridoxal-5-Phosphate is the metabolically active form of vitamin B6 and is involved in numerous processes in the body. Pyridoxal-5-Phosphate usage may inhibit pituitary cell proliferation, indicating it may be used to help with symptoms of hormone-secreting pituitary adenomas. Pyridoxal-5-Phosphate may also suppress the rise in prolactin and increase growth hormone levels induced by exercise. A combination of Pyridoxal-5-Phosphate and L-dopa (both components of Growth Factor XT) may lead to a greater decrease in prolactin than either ingredient alone (33-37).
BioPerine® is a patented extract from piperine (Piper nigrum L, aka black pepper), commonly used in nutraceuticals to potentiate the effects of compounds. BioPerine® works by inhibiting enzymes (such as CYP3A4, CYP 450, and P-glycoprotein enzymes) that metabolize the supplements we take. When BioPerine® inhibits these enzymes, the enzymes aren’t able to quickly break down ingredients, meaning you get stronger and longer lasting effects from the ingredients in Growth Factor XT. BioPerine® has several trials showing its efficacy (38-41).
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