PEScience High Volume

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Prepare to Feel the Volume We’ve all experienced the pump…that feeling of your muscles blowing up after doing a set of intense lifts during your workout. You do these sets, you feel the muscle fullness and see your arms swell in front of you, but within minutes of concluding your workout, you lose the pump. [...]

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Prepare to Feel the Volume

We’ve all experienced the pump…that feeling of your muscles blowing up after doing a set of intense lifts during your workout. You do these sets, you feel the muscle fullness and see your arms swell in front of you, but within minutes of concluding your workout, you lose the pump. That’s just how it is, and how it’s always been. Until now…

Pump Permanence

At PES, we’ve done some pretty groundbreaking things and have been the first company to bring a handful of novel and now-popular ingredients to the market. But we wanted to do something different here. We wanted to take the “pump product” category and permanently turn it on its head. And after over a year of diligent research and development, we have finally created a product that doesn’t just give you a pump that lasts 5 or 10 minutes after your workout; High Volume is the first ever product in the category with a formula focused on building muscle with pumps that last hours.

We had 3 goals with this product:

  1. 1.       The best pumps you’ve ever experienced
  2. 2.       The highest level of performance you’ve felt
  3. 3.       A product that doesn’t just give a quick pump, but is actually focused on the long-term benefits of an amazing pump

And we’ve undoubtedly taken these goals and crushed them.

Let’s take a closer look at how we achieved what was once deemed impossible…

Nitric Oxide Unlocked – The Missing Link in Muscle Growth

For a long time, it’s been unclear whether or not “the pump” actually improves muscle growth. Recent research now suggests that nitric oxide (NO), one of the major compounds that produces pumps during exercise, is directly involved in building muscle [1-3]. Not only does nitric oxide improve bioenergetics in muscle so that you can move more weight for more reps [1], but it also can in fact build muscle [2,3]. So what do we want to do? Elevate NO, and keep it elevated for hours!

But here’s the catch: most products do not use ingredients that actually elevate NO in the body. And even the few that do, you’ve deflated by the time you get home from the gym. They may induce pumps, but these pumps are short-lived and do not produce the lasting effects that true nitric oxide increases can provide.

So naturally, in High Volume, we addressed both these issues. We found compounds that actually elevate NO, and we found a way to bypass the issue of NO’s short half-life, or active time in the body. And this is how we’ve permanently redefined the pump category…and permanently changed the understanding of why a pump is important.

High Volume | More of What You Want, None of What You Don’t

Pure L-Citrulline (no Malate here…)

L-Citrulline is one of the best NO ingredients on the market, but it is constantly used at tiny serving sizes. We even found it even provided benefits outside of the NO boost! This is due to L-citrulline’s unique ability to detoxify the body and muscles by removing ammonia, a muscle protein waste product, from your body.

But stop wasting your money on Citrulline Malate in a pre-workout product. You need Pure L-Citrulline. The citrulline malate found in products is just a blend of L-Citrulline and L-Malate. That means, the 4 grams of L-Citrulline that is found in High Volume is equivalent to the citrulline content in 8 grams of citrulline malate! That’s what we do at PES…we give you more of what you need for NO.

Malate is a good ingredient to take with BCAAs or intra-workout, but it has absolutely no use for pumps or increasing NO. So why are you taking half the amount of citrulline?

Nitrates – All Day Pumps?!

Remember…the key is to increase NO, do it quickly, and have it last for its long term benefits. In our search for a long-lasting pump ingredient, we focused on a compound that has been used by for the purpose of venodilation (expansion of your veins for roadmap vascularity and pumps). This compound is nitrate.

Nitrates, in addition to having an 8+ hour half-life for long lasting pumps, use a unique pathway to boost NO. To be specific, nitrates bypass the enzyme that L-Citrulline relies on, eNOS, which has a “saturation point” at which no further supplementation can increase its activity. This means that you can bypass the body’s natural restriction points for unparalleled muscle pumpswith the combination for nitrate and citrulline. You see, nitrates act as an “NO donor,” meaning they convert to NO directly via a 2-step process…no enzymes or restriction points involved [7]!

In addition to all of this, it looks like nitrates can actually augment protein synthesis in muscle tissue…which means they can also have a purpose independent of NO elevation [5, 6]!

Some of you might be asking, why did we use Arginine Nitrate as our nitrate source out of all the possible amino-nitrates? Easy answer…the nitrate is increasing NO, but the arginine plays a very important role when combined with nitrate. We found that arginine actually has the ability to reduce nitrate tolerance [4]! This makes Arginine Nitrate the most superior form of nitrate available. Gone are the days of diminishing returns…High Volume gets BETTER, not worse, with time.

Agmatine Sulfate – The Two-Fold Pump

Agmatine is a cousin of arginine that has recently come under the public spotlight because it induces vasodilation.

Agmatine also appears to be a selective nutrient partitioner in animals. It causes the release of powerful hormones from the adrenal glands…hormones that move your glucose into muscle tissue where they can get stored as glycogen [8].

That’s right…now we are not just talking about NO pumps, but pumps that work completely independent of NO!

Changing the Game

AmentoMAX – Strength Unparalleled

A few months ago AmentoMAX was released as a single ingredient product. As we expected, it quickly took off with popularity and raving fans for its pre-workout use. So of course, we knew we had to use AmentoMAX here in High Volume, to bring the unique angle to every workout.

The final trigger in muscle contraction is an increase in calcium in the muscle cell. The calcium binds to key muscle proteins that result in contraction, and it has been shown that the more calcium released into the muscle cell, the more force is produced.

Amentoflavone possesses the highly unique ability to increase calcium release, in vitro; in fact, essentially only one other commonly found compound shares this mechanism: caffeine. Unlike caffeine though, Amentoflavone is 20 times more potent at increasing muscle calcium than caffeine in vitro [9]. This increase in muscular calcium concentration is part of the reason why caffeine is an ergogen (capable of improving exercise performance), and Amentoflavone achieves this effect in a more powerful manner without the stimulation of caffeine. AmentoMAX initial anecdotal feedback shows it gives a nice mental edge, without the physical stimulation.

So that’s performance, but what about pumps? Amentoflavone is a mixed Phosphodiesterase (PDE) inhibitor in vitro, which is yet another pathway to pumps that you’re not going to find in other products [10].

Rutaecarpine – Synergy with AmentoMAX

Rutaecarpine first caught our attention because it boosted NO through more mechanisms than we could count. It didn’t use eNOS, or nitrate-nitrite, or even the imidazoline/A2A receptors of agmatine…it used pathways such as inhibition of vasoconstricting prostaglandins and hormones, direct NO elevation, and most importantly, potentiation of the cGMP pathway [11-14]. The action on the cGMP pathway complemented perfectly with AmentoMAX, making these two ingredients a real 1-2 punch.

L-Norvaline Verdict: FAIL

Every time we see L-Norvaline pop up in a product we scratch our heads…it just clearly does not make sense. Remember how we said we would give you more of what you want, and none of what you don’t? Norvaline is a perfect example of what you don’t want in a pre-workout…or any supplement for that matter. L-Norvaline should impart no NO elevation in generally healthy, exercising people. The research on Norvaline has been extrapolated and attempted to be stretched into something beneficial for pumps and performance, but what the research actually says is that Norvaline will only work in individuals with cardiovascular problems [14, 15], as it is only these people who have suboptimal eNOS activity at baseline. So why are you paying for it? I have no idea…

So we figured we’d done it. Here we had not one, not two, not three, not four, BUT FIVE ingredients that all acted to improve pumps.  Some working in tandem with one another, some working through independent pathways. What more could you want? Well…we got an idea.

Let’s continue to pursue our original 3 goals. Rather than just attacking vasodilation, blood vessel expansion, and glucose pumps, let’s also try to cause muscle and plasma volumization.

And hence the name “High Volume” was born…

HydroMax® and Taurine – High Volume Achieved

There are two main body “compartments” that we want to expand/volumize to create a long lasting pumped-up look: the first is your plasma, which is essentially the bloodstream, and the second is the intracellular space, which is your muscle cells. The bloodstream is in close contact with your muscle cells, so by expanding both of these at the same time, we create “pumps on pumps” for maximum volumization…aka High Volume!

HydroMax® – Plasma Volumization

HydroMax® is a high potency glycerol compound. Glycerol is an ingredient that gets transported to your plasma after ingestion…and it doesn’t leave the plasma for a long time. While in the plasma, glycerol sucks up water by acting as a sponge. The net result is hyperhydration. The long half-life of glycerol in the plasma means that with repeated use of High Volume as your preworkout, you volumize your plasma more and more.

Unlike some pump products that show diminishing effects with use, High Volume can do just the opposite…with each use, you can achieve a greater level of “High Volume.”

Also importantly, many glycerol products on the market use glycerol monostearate, which is less than ¼ glycerol and ¾ saturated fat. HydroMax® is 65% glycerol, and there’s no nasty floating grit to clog up your shaker and stick in-between your teeth.

Taurine – Muscle Volumization

Taurine is a compound that localizes primarily to the intracellular muscle compartment, and like glycerol, where taurine goes, water follows. This makes taurine a great compound to complement HydroMax®. Taurine is one of the most underrated compounds on the market, mostly because it is rarely used properly. Here is High Volume, it works in tandem with HydroMax®, where its abilities can shine through.


You have never experienced anything like this. Every product tells you that…but what company continues to deliver? We don’t put our money in mass marketing, we put it into developing the best product for the consumer. If you’ve been following the science closely, you don’t need me to tell you that. Our testers came out of their workouts unable to reach their arms over their heads from the massive pumps…hell, they came out of their workouts looking like they wore a shirt two sizes too small from all the pump they experienced. The best quote we got from one of our initial testers was, “I think my pumps got pumps”!

And it got better with every workout. We did what they said was impossible…we created a product that actually elevated Nitric Oxide to a new level. Once you experience High Volume, you will call every other pump product flat. It’s time to FEEL THE VOLUME, and get with the brand that brings the formulas that set the standard.

You’ll look forward to your next workout knowing you’ll walk out of the gym looking like a bigger version of the guy who walked in. You’ll see size gains and expansion of muscle tissue at a rate you’ve never seen before…and you’ll constantly want to train another group of muscle to see what High Volume can do next.

This is the product that has redefined the pump category permanently.

This is High Volume.




  1. Smith, L. W., J. D. Smith, and D. S. Criswell. “Involvement of Nitric Oxide Synthase in Skeletal Muscle Adaptation to Chronic Overload.” Journal of Applied Physiology 92.5 (1985): 2005-011. Web.
  2. Buono, Roberta, Chiara Vantaggiato, Viviana Pisa, Emanuele Azzoni, Maria Teresa Bassi, Silvia Brunelli, Clara Sciorati, and Emilio Clementi. “Nitric Oxide Sustains Long-Term Skeletal Muscle Regeneration by Regulating Fate of Satellite Cells Via Signaling Pathways Requiring Vangl2 and Cyclic GMP.” Stem Cells 30.2 (2012): 197-209. Web.
  3. Palma, Clara, and Emilio Clementi. “Nitric Oxide in Myogenesis and Therapeutic Muscle Repair.” Molecular Neurobiology 46.3 (2012): 682-92. Web.
  4. MacAllister, R. (2000).  Arginine and nitrate tolerance. Br J Pharmacol.
  5. Lee, J. (2010). Effect of vasodilation on the response of muscle protein synthesis to insulin in aging. J Clin Endocrinol Metab.
  6. Timmerman KL, et al. (2010). Insulin stimulates human skeletal muscle protein synthesis via an indirect mechanism involving endothelial-dependent vasodilation and mammalian target of rapamycin complex 1 signaling. J Clin Endocrinol Metab.
  7. Lundberg JO, et al. (2008). The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics. Nat Rev Drug Discov.
  8. Hwang, S.-L., I.-M. Liu, T.-F. Tzeng, and J.-T. Cheng. “Activation of Imidazoline Receptors in Adrenal Gland to Lower Plasma Glucose in Streptozotocin-induced Diabetic Rats.” Diabetologia 48.4 (2005): 767-75. Web.
  9. Suzuki, A. et al. (1999). Properties of amentoflavone, a potent caffeine-like Ca2+ releaser in skeletal muscle sarcoplasmic reticulum. European Journal of Pharmacology.
  10. Saponara, R., and E. Bosisio. “Inhibition of CAMP-phosphodiesterase by Biflavones of Ginkgo Biloba in Rat Adipose Tissue.” Journal Of Natural Products 61.11 (1998): 1386-387. Web.
  11. Li, Y. et al. (2014). Rutaecarpine inhibits angiotensin II-induced proliferation in rat vascular smooth muscle cells. Chin J Integr Med.
  12. Liu, Y. et al. (2008). Reduction of asymmetric dimethylarginine in the protective effects of rutaecarpine on gastric mucosal injury. Can J Physiol Pharmacol.
  13. Choi, Y. (2006). Anti-inflammatory principles from the fruits of Evodia rutaecarpa and their cellular action mechanisms. Arch Pharm Res.
  14. Wang, G. et al. (1999) Vasorelaxing action of rutaecarpine: effects of rutaecarpine on calcium channel activities in vascular endothelial and smooth muscle cells. J Pharmacol Exp Ther.  
Weight 1.5 lbs


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