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Korean Mistletoe Extract: Korean Mistletoe is a semi-parasitic plant that grows on various trees and that has been used for centuries to treat several human ailments. It is believed to have anti-tumor, immunostimulatory, anti-diabetic, and anti-obesity properties. There are several extracts of Mistletoe and the chemical composition of them depends on the species of the host tree, harvest time and extract preparation. Recent research has focused on Korean mistletoe extract (KME) for use as a treatment for the prevention and reversal of muscle wasting conditions. The research on KME is nothing short of exceptional and quite beneficial for athletes. It has been shown to increase endurance exercise by potentiating mitochondrial function and increase muscle hypertrophy while preventing muscle atrophy. It induced those results by stimulating myogenesis,phosphorylation of Akt signaling pathway(THE anabolic machinery) PGC-1α and GLUT4 expression (linked to insulin secretion and sensitivity, perfect partner for higher IGF-1 expression stimulated by Hesperidin and Rikkunshito) and inhibited atrogin-1. Although KME is derived from a semi-parasitic plant, clinical studies in humans have found no negatives side effects. In fact, studies have shown it has been well tolerated and there have been no indications of liver or kidney toxicity.
Hesperidin Methyl Chalcone: A sugar molecule naturally found in citrus fruits, this compound has been shown to have the ability to influence muscle tissue formation. It promotes accelerated muscle recovery allowing you to lift harder, longer, and more often.
Gentian Root Extract 10:1: an herbal bitter that helps to stimulate ghrelin secretion helping to increase your appetite. Additionally, increased ghrelin translates to increased growth hormone.
Rikkunshito: A Japanese herb that has been shown in research to regulate the secretion, receptor sensitization, and degradation of Ghrelin (hunger hormone). Research studies have shown this ingredient to be effective at treating patients who suffer from Cachexia, a condition that causes the loss of appetite and lean body mass implying that it helps to increase appetite and lean body mass. The increased appetite is a result of increased Ghrelin. Increased Ghrelin also stimulates the release of growth hormone which breaks down fat and increases muscle mass.
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