NEW Splyce™ by Driven Sports is an intra-workout fuel that is based on branch-chain amino acids (BCAA), with a supporting cast of ingredients that have been shown to promote muscle building and enhance muscle volume.
Splyce™ can allow you to train harder and for longer because it provides the amino acids that are metabolized directly in the muscle. Not only can this help switch off catabolic enzymes that can break muscle down, it can also delay the fatigue that can hinder a long, hard workout.
During training, muscle cells are striving to generate ATP from food-derived fuel stores, and the harder you work the more rapidly this process powers your workout. However, one damaging byproduct – superoxide – can wreak havoc on a working cell. Think about it like your body rebelling against you for putting it through the intense training it takes to grow.
Taurine has been shown to increase exercise time to exhaustion by decreasing oxidative stress during exercise, protecting cells from this damaging molecule produced during intense training and increased workload. (1, 2) We don’t want anything stopping you from going beyond your limits, and taurine’s ability to stave off exhaustion provides ideal physical performance enhancement to complement the relentless mental drive that carries you through your most intense workouts.
With Taurine, you can put that call to quit on hold and protect your muscular machinery from chemical injury. (3)
In human subjects, TMG has been shown to delay fatigue during exercise, making its partnership with taurine ideal in Splyce™ – but that’s only the beginning. (4) TMG also kept athletes working at full capacity throughout training sessions, supporting steady power, force and intensity significantly in both bench press and squat training. (5)
Finally, researchers who have studied TMG as an ergogenic aid in humans hypothesize that one of its key mechanisms is acting as an osmolyte, pulling water into skeletal muscles, increasing size and decreasing susceptibility to fatigue. (6) These are all scientifically validated mechanisms that contribute to Splyce™, the new breed in intra-workout performance.
We know that dietary protein intake stimulates muscle growth and we also know that muscle protein synthesis decreases while muscle protein degradation increases during exercise. Ideally, we want to stop these metabolic effectors from putting muscle growth on hold, and digestive processes during training don’t exactly make whey protein the most attractive option to keep this process from negatively affecting your progress in the gym. (7)
It turns out that one essential amino acid in particular, L-leucine, is more than just a building block for muscle, but also a pharmacological agent.*
1.8g L-leucine alone (one of the three BCAA’s in Splyce™) is enough to elicit maximal muscle protein synthesis in healthy adults. (8) This happens when leucine enters skeletal muscle and activates a growth factor protein called mTOR; however, there are other players in the process that are necessary to keep muscle protein synthesis churning. Specifically, we’re talking about the other two BCAA’s, l-isoleucine and l-valine.
So, adding another 1.8g of the other two should be enough to fix the problem, right? Wrong. Not only is the combination crucial to muscle growth, but the ratio of the three is too, as is shown in most clinical research utilizing BCAA’s in athletes. That ratio appears to be 2:1:1, or half as much isoleucine and valine for every leucine, first because that ratio mimics the BCAA content of animal protein and second because the human body seems to metabolize BCAA’s best in this 2:1:1 ratio. (9, 10)
Recent research shows that even when amino acid levels are elevated in your blood after a meal, muscle protein synthesis grinds to a halt after 2 hours. (11) However, raising BCAA concentrations in the blood with a quick, clinically effective dose of BCAA’s, can reignite muscle protein synthesis, extending your normal physiological response past the 2-hour hurdle.
Supplementing with a 2:1:1 ratio of BCAA’s either during training or between meals gives you a scientifically proven edge in muscle protein synthesis, no matter what your athletic goals, and further, BCAA supplementation during exercise has been shown to attenuate mental fatigue and improve cognitive performance by competing for L-tryptophan uptake in the brain. (12) BCAA’s truly do have the potential to prolong the integrity of your mind-muscle connection during long bouts of intense training.*
In the days when protein connoisseurs were almost always engaged in some type of debate over filtration methods and protein sources, one of the most heavily scrutinized filtration processes was ion-exchange filtration.
Ion-exchange filtration is a harsh, unforgiving process, and some specific peptides found in whey protein are delicate – they simply don’t survive the process. These special peptides are known as whey microfractions, and one found abundantly in whey is a called beta-lactoglobulin. Now it’s important to note that this microfraction is abundant in cow’s milk, but it has no known function in humans. (13) However, it’s “sister-peptide,” alpha- lactalbumin is both scarce in cow’s milk and highly abundant in human breast milk.
Intuitively, we always look for innovative ways to accelerate muscle growth naturally and safely, and there is a lot of promise for alpha-lactalbumin for clinically evident reasons.
First, its role in human growth during early stages in life is well established and clinically validated. In fact, a baby formula enriched with alpha-lactalbumin but lower in total protein by 1.3g/l resulted in equivalent, healthy weight gain against infants fed the higher protein formula and the researchers suggest that the BCAA content, which is naturally quite close to 2:1:1, of alpha-lactalbumin could be responsible for the compensatory weight gain. (14)
Second, and perhaps equally important, is alpha-lactalbumin’s role in lactose metabolism where it activates the enzyme that converts glucose and galactose to lactose which may decrease blood glucose and therein increase fat oxidation; the exact result researchers observed in rats fed an alpha- lactalbumin enriched supplement prior to being subjected to a bout of exercise. (15)
Often you’ll see products claim an “increase in lean mass” in an organisms fed an ingredient they use in a supplement; however, lean mass does not necessarily mean muscle mass…except in this case where the results at the end of that study mentioned above showed increased MUSCLE mass and decreased fat mass in the alpha-lactalbumin group against both glucose and whey protein groups. (15)
As always we went above and beyond, setting out to create more than just a reliable, delicious, top-quality BCAA supplement – we bring new products to market with every athlete in mind, and Splyce™ is just another rung in ladder to your ultimate natural performance enhancement arsenal.
The comprehensive blend of a scientifically-backed fatigue reducing matrix, growth stimulating amino acids, and every athlete’s first growth stimulator, alpha-lactalbumin, will give you the precious edge that Driven Sports has been bringing to natural athletes for years, helping you seek and destroy – every rep, every set, beyond your limits.*
1. Zhang M1, Izumi I, Kagamimori S, Sokejima S, Yamagami T, Liu Z, Qi B. Role of taurine supplementation to prevent exercise-induced oxidative stress in healthy young men. Amino Acids. 2004 Mar;26(2):203-7. Epub 2003 May 9.
2. Silva LA1, Silveira PC, Ronsani MM, Souza PS, Scheffer D, Vieira LC, Benetti M, De Souza CT, Pinho RA. Taurine supplementation decreases oxidative stress in skeletal muscle after eccentric exercise. Cell Biochem Funct. 2011 Jan-Feb;29(1):43-9.
3. Huxtable RJ. Physiological actions of taurine. Physiol Rev. 1992 Jan;72(1):101-63.
4. Hoffman JR, Ratamess NA, Kang J, Rashti SL, Faigenbaum AD. Effect of betaine supplementation on power performance and fatigue. J Int Soc Sports Nutr. 2009 Feb 27;6:7.
5. Lee EC, Maresh CM, Kraemer WJ, Yamamoto LM, Hatfield DL, Bailey BL, Armstrong LE, Volek JS, McDermott BP, Craig SA. Ergogenic effects of betaine supplementation on strength and power performance. J Int Soc Sports Nutr. 2010 Jul 19;7:27.
6. Lever M, Slow S. The clinical significance of betaine, an osmolyte with a key role in methyl group metabolism. Clin Biochem. 2010 Jun;43(9):732-44.
7. Norton LE1, Layman DK. Leucine regulates translation initiation of protein synthesis in skeletal muscle after exercise. J Nutr. 2006 Feb;136(2):533S-537S.
8. Glynn EL1, Fry CS, Drummond MJ, Timmerman KL, Dhanani S, Volpi E, Rasmussen BB. Excess leucine intake enhances muscle anabolic signaling but not net protein anabolism in young men and women. J Nutr. 2010 Nov;140(11):1970-6.
9. Campbell B1, Kreider RB, Ziegenfuss T, La Bounty P, Roberts M, Burke D, Landis J, Lopez H, Antonio J. International Society of Sports Nutrition position stand: protein and exercise. J Int Soc Sports Nutr. 2007 Sep 26;4:8.
10. Shimomura Y1, Murakami T, Nakai N, Nagasaki M, Harris RA. Exercise promotes BCAA catabolism: effects of BCAA supplementation on skeletal muscle during exercise. J Nutr. 2004 Jun;134(6 Suppl):1583S-1587S.
11. Norton, L., E., & Wilson, G. J. (2009). Optimal protein intake to maximize muscle protein synthesis: Examinations of optimal meal protein intake and frequency for athletes. Agro Food Industry High-Tech, 20(2): 54-57.
12. Blomstrand E. Amino acids and central fatigue. Amino Acids. 2001;20(1):25-34.
13. Kontopidis G1, Holt C, Sawyer L. Invited review: beta-lactoglobulin: binding properties, structure, and function. J Dairy Sci. 2004 Apr;87(4):785-96.
14. Trabulsi J1, Capeding R, Lebumfacil J, Ramanujam K, Feng P, McSweeney S, Harris B, DeRusso P. Effect of an α-lactalbumin-enriched infant formula with lower protein on growth. Eur J Clin Nutr. 2011 Feb;65(2):167-74.
15. Bouthegourd JC1, Roseau SM, Makarios-Lahham L, Leruyet PM, Tomé DG, Even PC. A preexercise alpha-lactalbumin-enriched whey protein meal preserves lipid oxidation and decreases adiposity in rats. Am J Physiol Endocrinol Metab. 2002 Sep;283(3):E565-72.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Serving Size: 1 Scoop (8.95 grams)
|* Percent Daily Values are based on a 2000 calorie diet.|
** Percent Daily Values not established.OTHER INGREDIENTS: Malic Acid, Natural & Artificial Flavors, Acesulfame Potassium, Silica, Sucralose, FD&C Red #40.
As a dietary supplement, mix 1 scoop (8.95 grams) with 10-12 ounces of cold water. Splyce can be consumed before, during, and after your workout, as well as in between meals, to boost your amino acid intake. Store in a cool, dry place.
Read and follow all label directions. Do not use this or any other supplement before obtaining clearance from your licensed healthcare practitioner. For use by healthy adults only. Do not use if you are pregnant, nursing or may become pregnant. Do not use if you are being treated for or could devlop any medical or psychiatric condition, even those minor in nature. Do not use if you are taking any prescription or recreational drugs. Discontinue use and consult a physician if any adverse reactions occur. Store in a cool, dry place out of direct light. Keep lid tightly closed and out of reach of children and animals.
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