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Antaeus Labs Aegis

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Antaeus Labs' Aegis: "The Shield of The Gods"!**Improved Formula for Ultimate Liver Protection**There are many types of liver injury, but only one is normally associated with the use of oral androgens – cholestasis. This condition is defined as a failure of normal bile to reach the duodenum, which may be due to a number of [...]

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Antaeus Labs' Aegis: "The Shield of The Gods"!

**Improved Formula for Ultimate Liver Protection**

There are many types of liver injury, but only one is normally associated with the use of oral androgens – cholestasis. This condition is defined as a failure of normal bile to reach the duodenum, which may be due to a number of different pathological states between the hepatocyte and the ampulla of Vater. When one takes oral androgens (typically methylated at C17a) the physical structure of the hepatocyte is altered — microfilaments and canaliculi become less contractile. Disruptions in the canalicular bile salt export pump may also occur. This leads to impaired bile flow and the retention of highly cytotoxic hydrophobic bile salts. At low concentrations, these retained bile salts cause apoptosis; at higher concentrations, necrosis and severe liver damage.

This is where Aegis comes into the picture. It was designed with users of oral androgens in mind, and brings together the best anti-cholestatic ingredients available.

Tauroursodeoxycholic Acid:

  • Can prevent apoptosis during cholestasis. Toxic bile acids produce apoptosis Via fas- and TRAIL- death receptor mediated pathways. Both are, to some degree, dependent on the translocation of the ‘bax’ pro-apoptoic molecule from the cytosol of hepatocytes to the cell mitochondria. TUDCA prevents bax translocation, strongly stabilizes mitochondrial membranes, and activates the MAPK pro-survival pathway in hepatocytes. (1) These effects protect hepatocytes from bax-related apoptosis.
  • Is a hydrophilic bile acid, and its presence markedly shifts the bile pool towards hydrophilicity, which, to some extent, detoxifies it. When used consistently, especially at pharmacological doses, TUDCA (along with UDCA) eventually becomes the predominant bile acid in the liver and in general circulation. (2)
  • Directly stimulates bile secretion via modulating cellular signalling pathways in hepatocytes, such as ERK, src, PKC and others. These signalling pathways generally phosphorylate, or activate, the bile salt export pump (BSEP) and other processes
  • involved in bile export/secretion. (For example, PKC-alpha-mediated secretion of HCO3-.) (3, 4, 5)

Polyenylphosphatidylcholine:

  • Stabilizes cellular membranes and dilates bile canaliculi. This former effect has been shown to protect human cells from hydrophobic bile salt induced apoptosis (6), and the latter may serve to counteract the reduction in contractility seen in androgen-induced cholestasis. (7)
  • Oral androgen administration may decrease hepatic Na+, K+-ATPase, Ca2+, Mg2+-ATPase and F-actin levels — all of which may be restored, and even raised, by polyenylphosphatidylcholine administration. (8)
  • Is secreted into bile by hepatocytes, where it serves as a major component of the micelles in which bile acids are emulsified. Increased levels of biliary phosphatidylcholine reduces the cytotoxicity of bile acids, whereas phosphatidylcholine-secretion impairment (as is often seen in ABCB4 disease) is characterized by extremely severe cholestatic liver disease. (9)

N-acetylcysteine (NAC):

  • Is both a metabolite of, and a precursor to, glutathione, a naturally-occurring peptide that is important in the detoxification of lipophilic toxins in the liver. (10)
  • Functions as an anti-oxidant to minimise oxidative stress to cells caused by reactive oxygen species (ROS) (11)
  • Has anti-inflammatory properties and may reduce levels of inflammatory cytokines. (12)
  • May minimise muscle fatigue during exercise (13)

Chromium Picolinate:

  • May have some beneficial effects on glucose metabolism (14)
  • Demonstrates the ability to reduce the hepatic damage caused by toxins in animal models. (15,16)

References:

1. Joana D. Ameral, Ricardo J. S, Viana, Rita M. Ramalho, Clifford J. Steer, and Cecília M. P. Rodrigues (2009), “Thematic Review Series: Bile Acids: Bile acids: regulation of apoptosis by ursodeoxycholic acid”, J. Lipid Res, 50(9) 1721-1734. doi: 10.1194/jlr.R900011-JLR200

2. Trauner and Graziadei (1999), “Review article: mechanisms of action and therapeutic applications of ursodeoxycholic acid in chronic liver diseases”. Aliment. Pharmacol. Ther, 13: 979–995. doi: 10.1046/j.1365-2036.1999.00596.x

3. Dieter Häussinger, Anna Kordelia Kurz, Matthias Wettstein, Dirk Graf, Stephan Vom Dahl, Freimut Schliess (2003), “Involvement of integrins and Src in tauroursodeoxycholate-induced and swelling-induced choleresis “, Gastroenterology,124(5), 1476-1487

4. Ulrich Beuer (1997), “Effects of Bile Acids on Hepatocellular Signaling and Secretion”, YJBM, 70, 341-346

5. Frank Dombrowski, Bruno Stieger and Ulrich Beuers (2006), “Tauroursodeoxycholic acid inserts the bile salt export pump into canalicular membranes of cholestatic rat liver”, Laboratory Investigation, 86, 166–174. doi:10.1038/labinvest.3700371

6. Häussinger D, Kurz AK, Wettstein M, Graf D, Vom Dahl S, Schliess F (2003), “Involvement of integrins and Src in tauroursodeoxycholate-induced and swelling-induced choleresis”, Gastroenterology, 124(5), 1476-1487

7. Kolde G, Kessler E, Van Husen N, Themann H (1978), “Ultrastructural-morphometric analysis of polyenylphosphatidylcholine [PPC] treated cholestatic rat liver”, Z Gastroenterol, 16(10), 625-639

8. Françoise Chanussot and Liliane Benkoël (2003), “Prevention by dietary (n-6) polyunsaturated phosphatidylcholines of intrahepatic cholestasis induced by cyclosporine A in animals”, Life Science, 73(4), 381–392

9. Gonzales E, Davit-Spraul A, Baussan C, Buffet C, Maurice M, Jacquemin E (2009), “Liver diseases related to MDR3 (ABCB4) gene deficiency”, Front Biosci., 14, 4242-4256

10. Roes EM, Raijmakers MTM, Peters WHM, Steegers EAP. Effects of oral N-acetylcysteine on plasma homocysteine and whole blood glutathione levels in healthy, non-pregnant women. Clin. Chem. Lab. Med. 2002 May;40(5):496–8.

11. Dodd S, Dean O, Copolov DL, Malhi GS, Berk M. N-acetylcysteine for antioxidant therapy: pharmacology and clinical utility. Expert Opin Biol Ther. 2008 Dec;8(12):1955–62.

12. Arranz L, Fernández C, Rodríguez A, Ribera JM, De la Fuente M. The glutathione precursor N-acetylcysteine improves immune function in postmenopausal women. Free Radic. Biol. Med. 2008 Nov 1;45(9):1252–62.

13. Kerksick C, Willoughby D. The Antioxidant Role of Glutathione and N-Acetyl-Cysteine Supplements and Exercise-Induced Oxidative Stress. Journal of the International Society of Sports Nutrition. 2005 Dec 9;2(2):38.

14. Brownley KA, Von Holle A, Hamer RM, La Via M, Bulik CM. A double-blind, randomized pilot trial of chromium picolinate for binge eating disorder: Results of the Binge Eating and Chromium (BEACh) Study. J Psychosom Res. 2013 Jul;75(1):36–42.

15. Chen W-Y, Chen C-J, Liao J-W, Mao FC. Chromium attenuates hepatic damage in a rat model of chronic cholestasis. Life Sci. 2009 Apr 24;84(17-18):606–14.

16. Fan W, Liu A, Wang W, Zheng G, Teng A. Hepatoprotective activity of CrPic against alloxan-induced hepatotoxicity in mice. Biol Trace Elem Res. 2012 Nov;149(2):227–33.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Supplement Facts

Serving Size: 1 Capsule
Servings per Container: 180

 
 Amount Per Serving% Daily Value
Tauroursodeoxycholic Acid85 mg**
Polyenylphosphatidylcholine200 mg**
Vitamin B63 mg150%
 

* Percent Daily Values are based on a 2000 calorie diet.
** Percent Daily Values not established.

OTHER INGREDIENTS:  Gelatin, Silicon Dioxide, Microcrystalline Cellulose.

Directions:

As a dietary supplement, take three capsules twice daily. Take with meals. Keep refrigerated for optimal shelf-life. Use for a maximum of 8 weeks.

WARNING:

This product is for healthy adults over 18 years of age. Do not exceed recommended dosage. Consult a physician before using this or any dietary supplement. Do not use if you have any pre-existing medical condition or are taking any medication without consulting your physician. Store in a cool, dry place away from children.

Weight0.30 lbs

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